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General
- Zinc
pyrithione is a chemical compound used as an antifungal and
antibacterial agent. Zinc pyrithione is approved for
over-the-counter topical use in the United States as a treatment for
dandruff. It is the active ingredient in several anti-dandruff
shampoos such as Head & Shoulders.
- The
effectiveness of pyrithione zinc is well-established, but as with
many modern medicines that have evolved from time-tested remedies,
the way the drug actually works is less clear.
Uses
- If zinc
pyrithione is used as a preservative in cosmetic and hygiene
products the total proportion can be no more than 0,5 %. zinc
pyrithione has also started to be used as an active substance in
boat hull paint.
- Topical zinc
pyrithione appears to be a safe and effective treatment for
psoriasis. An aerosol preparation of zinc pyrithione (0.25%) in a
vehicle containing isopropyl myristate appears to be a safe and
effective treatment for psoriasis.
Analysis
- Zinc
pyrithione was found to be negative in mutation tests in bacteria
and Chinese hamster ovary cells. Similarly, no chromosomal
aberration was observed in human lymphocytes incubated in vitro in
the presence of zinc pyr ithione or in lymphocytes harvested from
monkeys
- The
mineralization of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-on (DCOI)
and zinc pyrithione was examined in laboratory tests with marine
coastal sediments.
Technology
- Zinc
pyrithione has been used as a booster biocide in antifouling paints
of ships. For its environmental risk assessment, a direct analyzing
technique of zinc pyrithione has been developed using HPLC-MS
without transforming to other substances.
- There was a
focus to extend for the first time the analytical utility of SPE and
LC-MS technique for the isolation and identification of ZnPT
Photolytic transformation products.
Market
- According to
one investigation in general stores and on the Internet to try and
identify which dandruff shampoos contain zinc pyrithione. In this
investigation, five different brands of dandruff shampoo containing
zinc pyrithione are sold in general stores.
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