|
General
- Transdermal
delivery of a drug product which is currently approved as oral dosage
form, allows for the avoidance of first pass metabolism by the liver and
the delivery of a more even level of the therapeutic agent over the
course of 24 hours. Dermal patches are the most common form of
transdermal delivery of drugs.
- Transdermal drug
delivery provides excellent control of the rate of delivery directly
into the bloodstream. It also offers a predictable pharmacokinetic
profile and constant drug levels over extended periods of time without
the extreme peak/trough fluctuations inherent in oral administration.
And discontinuation of therapy can be achieved immediately by simply
removing the patch
Technology
- Transdermal
delivery of therapeutic agents has been used successfully for
several decades. Transdermal systems for hormone replacement
therapy, smoking cessation, and pain management are well accepted;
however, there have been challenges in expanding use of the
technology to the delivery of peptides, proteins, and other
macromolecules.
- Throughout the
past 2 decades, the transdermal patch has become a proven technology
that offers a variety of significant clinical benefits over other
dosage forms. Because transdermal drug delivery offers controlled
release of the drug into the patient, it enables a steady
blood-level profile, resulting in reduced systemic side effects and,
sometimes, improved efficacy over other dosage forms. In addition,
because transdermal patches are user-friendly, convenient, painless,
and offer multi-day dosing, it is generally accepted that they offer
improved patient compliance
Uses
- Transdermal
delivery of medications to veterinary patients is becoming
increasingly popular. An effective, non-invasive method of
medicating animals is welcomed by veterinarians and owners alike.
- Advances in
molecular biology have given us a wide range of protein and
peptide-based drugs that are unsuitable for oral delivery because of
their high degree of first-pass metabolism. Though parenteral
delivery is the obvious answer, for the successful development of
commercial chronic and self-administration usage formulations it is
not the ideal choice. Transdermal delivery is emerging as the
biggest application target for these agents, however, the skin is
extremely efficient at keeping out such large molecular weight
compounds and therapeutic levels are never going to be realistically
achieved by passive absorption.
Market
- The market for
transdermal products has been in a significant upward trend that is
likely to continue for the foreseeable future. While it is true that
product approvals for new Transdermal drug delivery products have
not exploded as some predicted following the rapid success of
Transdermal drug delivery nicotine products in the early and mid
90s, an increasing number of Transdermal drug delivery products
continue to deliver real therapeutic benefit to patients around the
world.
- The outlook
for continued growth of the Transdermal drug delivery market is very
optimistic. Market analysts forecast a low double-digit compound
annual growth rate for the US Transdermal drug delivery market
throughout the next decade. Given the recent trend and product
pipeline, this may actually under predict the potential of the
Transdermal drug delivery market throughout this time period
Entrepreneur who
want the information on "Analysis ,Properties and Function, Technology,
Applications, Product, Processing, Software Providers, Patent,
Consultants, Company Profiles, Reports, Market, Projects, Guides"
can
Order CD-ROM Today |
Growth and Cultivation, Products, Processing, Technology, Market, Uses,
Suppliers and Buyers
