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General
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Teniposide is a topoisomerase inhibitor.
Teniposide produces its anti-cancer effects by inhibiting an enzyme,
topoisomerase, which is responsible for maintaining structural
function and integrity of DNA. By inhibiting the normal activity of
topoisomerase, teniposide inhibits proper DNA synthesis, ultimately
causing cellular death.
- Teniposide is
insoluble in water and ether. It is slightly soluble in methanol and
very soluble in acetone and dimethylformamide
Process
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Podophyllotoxin is the starting material for the semi-synthesis of
the anti-cancer drugs etoposide, teniposide and etopophos. These
compounds have been used for the treatment of lung and testicular
cancers as well as certain leukemias.
- Currently, the
commercial source of podophyllotoxin is the rhizomes and roots of
Podophyllum emodi Wall. (syn. P. hexandrum Royle), Berberidaceae, an
endangered species from the Himalayas
Uses
- Teniposide is
used in the treatment of acute lymphoblastic leukemia (blood cancer)
in children
Market
- As the
population ages in America, cancer is expected to be one of the
leading causes of death. It is estimated that the world market in
cancer-fighting pharmaceuticals will grow at a rate of approximately
8.0% annually with expected sales to reach US$14.7 billion in 2002.
- The world
market for cancer therapeutics is growing at a brisk double-digit
pace, with revenues surpassing $40 billion this year
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