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General
- Streptomycin is an
antibiotic drug.
- It is derived from
the actinobacterium Streptomyces griseus.
- Streptomycin is an
antibiotic that inhibits both gram positive and gram negative bacteria.
- Streptomycin is a
water-soluble aminoglycoside.
Biosynthesis
- Streptomyces strains
isolated from soil were found to possess various numbers of genes from
the streptomycin biosynthesis cluster.
- Protein involved in
the synthesis of streptomycin.
- Myo-inositol,
especially in combination with arginine, enhances streptomycin
production.
- The biosynthesis of
streptomycin in Streptomyces griseus has been studied by adding
D-[3,4-14C2]glucose or D-t1,3-14C2]glucose to the growth medium and
degrading the streptomycin produced.
Application
- Streptomycin is
applied as a potential control treatment for walnut blight.
- Streptomycin is
purified from the fermentation of the actinomycete Streptomyces griseus
and used in a variety of pharmaceutical applications.
- Streptomycin has an
effect on arrhythmias induced by an increase of ventricular wall stress
in the rat heart.
- A commercial source
of streptomycin has been used to induce seedlessness in the seeded grape
cultivar Rubi (Italia Red).
Market
- Samples of Chinese
honey and blended honey containing Chinese honey tested positive for
Chloramphenicol and Streptomycin, antibiotics used in human medicine.
- India, today, is a
major producer of streptomycin. (Production has almost stopped in all
the major developed countries). Indigenous demand is fully met from
indigenous supply.
- Estimated demand
matrix may be generated for each drug especially for streptomycin and
rifampicin.
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