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General
- Propylene
glycol, known also by the systematic name propane-1,2-diol, is an
organic compound.
- Propylene
Glycol is usually a faintly sweet, odorless, and colorless clear
viscous liquid that is hygroscopic and miscible with water,
acetone, and chloroform.
- Propylene
glycol contains an asymmetrical carbon atom, so it exists in two
stereoisomers.
- Propylene
Glycol is an petroleum derivative that act as solvents,
surfactants, and wetting agents. They can easily penetrate in to
the skin, and can weaken protein and cellular structure.
Process
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Industrially propylene glycol is produced by propylene oxide
hydration.
- Pure
optical isomers can be obtained by hydration of optically pure
propylene oxide.
- Propylene
glycol can also be converted from glycerol, a biodiesel
byproduct.
- Propylene
glycol is produced from propylene oxide by liquid phase
hydrolysis with excess water in the presence of a small
concentration of sulfuric acid as the catalyst.
Application
-
Propylene glycol is used as a moisturizer in medicines,
cosmetics, food, toothpaste, mouth wash, and tobacco products
.
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Propylene glycol is used as a medical and sexual lubricant.
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Propylene Glycol is used as an emulsification agent in
Angostura and orange bitters and as a solvent for food colors
and flavorings.
- It is
used as a carrier in fragrance oils and as a less-toxic
antifreeze .
Report
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Patients with vulvodynia and interstitial cystitis may be
especially sensitive to propylene glycol.
- Post
menopausal women who require the use of an estrogen cream
may notice that brand name creams made with propylene glycol
often create extreme, uncomfortable burning along the vulva
and perianal area.
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Propylene glycol does not cause sensitization and it shows
no evidence of being a carcinogen or of being genotoxic.
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Prolonged contact with propylene glycol is essentially
non-irritating to the skin.
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