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In the
development of biodegradable elastomeric polymer called
poly(glycerol-sebacate) (PGS) prepared by polycondensation of glycerol and
sebacic acid. To facilitate nanopatterning of the polymer by molding
methodologies, we chemically modified the PGS through the incorporation of
acrylate side groups to form the linear poly(glycerol-sebacate-acrylate) (PGSA).
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To
fabricate photocurable biodegradable elastomers at room temperature, a three
step process was employed. In the first step, a pre-polymer from glycerol
and sebacic acid was created. In a second step, functional hydroxyl groups
on backbone of the PGS pre-polymer were acrylated and subsequently purified.
In a third step, the PGS-acrylate (PGSA) was polymerized with UV light in
the presence of a photoinitiator. This elastomer is referred to as
photocured PGSA.
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PGSA can
be cured rapidly at ambient temperatures to form polymeric networks with a
wide range of mechanical properties and in vitro enzymatic degradation and
hydrolysis profiles.
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The porous
PGSA scaffolds can provide a logistical template for 3D growth of cells and
tissue engineering. The porous scaffold prepared from a photocurable
elastomer, poly(glycerolcosebacate)- acrylate (PGSA). The scaffold porosity,
swelling, mass loss, toxicity and mechanical properties, suggest that porous
PGSA could be used to support the growth and differentiation of encapsulated
cells.
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