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General
- Peptides (from the
Greek πεπτος, "digestible") are the family of short molecules formed
from the linking, in a defined order, of various α-amino acids.
- Proteins are
polypeptide molecules.
- Peptide solubility is dependent on the amino acid content of the
peptide.
- Most peptides are stable at -20°C indefinitely, especially if they
are lyophilized and stored in a dessicator.
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BNP,
B-type Natriuretic Peptide
is a 32 amino
acid polypeptide initially found in brain but later found abundant in
cardiac ventricle tissues.
Production Process
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The peptide is present in large amounts in milk, and
PTHrP mRNA has been shown to be present in high amounts in lactating
mammary gland.
-
Free amino acids are undoubtedly the least expensive
components with which peptide synthesis is performed.
-
Endogenous antimicrobial peptides (AMPs) are small amino
acid–based molecules that have the capacity to kill microbes and are
produced by the host organism.
Glucagon-like peptide-1 (GLP-1) and glucagon share a
common precursor, preproglucagon, which upon tissue-specific processing
leads to production of GLP-1 in the intestine and glucagon in the
pancreas.
Synthesis
-
The Peptide Synthesis
Service provides a complete range of services including cleavage, HPLC
purification, quality assurance analysis and a variety of amino acid
derivatization/labeling techniques.
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Oligopeptides are
synthesized with an Applied Biosystems Model 430A instrument using FMOC
based chemistry and uronium salt type activation methodologies
Fluorous chemistry is the first new orthogonal phase
available for peptide synthesis
Solid phase peptide synthesis consists of assembling
amino acids from the C-terminal to the N-terminal.
Application & Technology
-
Synthetic
peptides have a wide variety of uses ranging from structure-function
analysis of sites within a protein, binding assays, receptor
agonists/antagonists, to immunogens for the production of antisera.
BNP prevents cardiac fibrosis during the pathologic
remodeling after cardiac injury.
Copper peptides and the lipo-peptide, are both used in
cosmeceuticals to stimulate collagen production and promote elasticity.
Peptides act as “messengers” from the brain to the body,
telling nerves and muscles to perform various functions.
The technology relates to a peptide immunotherapy approach to
modulate the immune response of T-cell epitopes to rhesus (RhD and RhCc/Ee)
antigens.
Market
- Peptides are widely used in creating medicines where the total
market size for peptide medicine is estimated to be approximately 10
billion USD.
- High technology barriers and limited number of players make the
generic peptide drug market an attractive opportunity for Indian
players.
- The U.S. holds 65% of the worldwide therapeutic peptides market,
Parmar says. Europe is 30% of the total, with Germany and the U.K. in
the lead. Japan dominates activity in Asia.
- Peptides used in drug formulation and
clinical trials account for nearly 93 per cent of the European
therapeutic peptides market with R&D comprising the remainder.
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