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General
- Nitro compounds
are organic compounds that contain one or more nitro functional
groups (-NO2).
- The nitro
compounds are colourless, somewhat pleasant smelling liquids.
- Nitro compounds
distil without decomposition and possess boiling points much higher
than those of the isomeric nitrous esters.
- Most of the
poly-nitro compounds are not volatile, but undergo decomposition on
heating .
Synthesis
- A wide range of
aromatic nitro compounds with tellurium powder in aqueous methanolic
ammonium chloride and resulted in selective reduction of the nitro
groups.
- Synthesis of
primary and secondary nitro compounds which involves treating alkyl
halides with sodium nitrite in dimethylformamide yields 5542% of
pure nitro compounds are obtained.
- Very frequent
method for preparation of aliphatic nitro compounds is oxidation of
primary amines with potassium permanganate.
Application
- The role of
reactive nitrogen oxide species (RNOS) in human disease states
characterized by inflammation, such as coronary atherosclerosis, has
largely been obtained from the quantification of 3-nitrotyrosine in
diseased tissues.
- Nitro-compounds
such as glycerol trinitrate (nitroglycerin), isosorbide dinitrate,
sodium nitroprusside, amyl nitrite and other agents produce
vasodilation by actions of cyclic guanine monophosphate (cyclic GMP)
synthesized through stimulations of cytosolic guanylate cyclase.
- Nitrate
simultaneously induced NADH- and NADPH-nitrate reductase activities
in rice seedlings.
- Rapid and
selective reduction of nitro compounds is of importance for the
preparation of amino derivatives.
Technology
- The adsorption of
several aromatic nitro compounds and the ion-exchange of heavy metal
ions on electro-oxidized carbon fibres have been investigated using
cyclic voltammetric and polarographic techniques.
- Nitro groups on
aromatic self-assembled monolayers(SAM)s on silver are selectively
converted to amino groups under irradiation technique with visible
light.
- Nitric oxide(NO)
has been detected as the product of thermal decomposition of
nitro-organics by IR spectroscopy, microwave spectroscopy, and
fluorescence techniques.
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