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General
- Nifedipine (brand
name Adalat, Nifedical, and Procardia) is a dihydropyridine calcium
channel blocker.
- Nifedipine is a high
blood pressure (hypertension) and migraine medication taken as a daily
pill.
- Nifedipine belongs to
a class of drugs known as calcium channel blockers (CCBs).
- Nifedipine comes as a
capsule and an extended-release tablet (long-acting) to take by mouth.
- It is a yellow
crystalline powder.
Process
- In wet spherical
agglomeration (WSA) process the nifedipine particles were agglomerated
by dropping a chloroform solution containing a bridging liquid.
- In spherical
crystallization(SC) process the nifedipine microspheres were prepared by
pouring a 56°C acetone solution containing 0.5% nifedipine into 100 mL
25°C water.
- Differential scanning
calorimetry(DSC) showed no change occurred during preparation of the
nifedipine microspheres.
- The nifedipine GITS
formulation provides a once-daily dosing regimen with a continuous and
slow release of the drug into the intestinal tract, resulting in a
smooth plasma concentration/time profile.
Uses
- Nifedipine is used
sometimes to treat migraine headaches, Raynaud's syndrome, congestive
heart failure, and cardiomyopathy.
- Nifedipine is used as
a coronary vasodilator and an antianginal in the treatment of coronary
insufficiency and angina of effort.
- 0.5% nifedipine
ointment is used in healing acute anal fissue and preventing its
progress to chronicity.
- The main function of
Nifedipine is vascular dilation associated with a decrease in peripheral
resistance and blood pressure.
- Nifedipine is a type
II calcium channel antagonist, which inhibits the influx of calcium ions
into myometrial and other cells and thereby reduces muscle
contractility.
- Nifedipine was more
successful in arresting preterm labor with less side effects and better
tolerability as compared to ritodrine.
Technology
- The conformation of
nifedipine, a cardiac and smooth muscle calcium ion channel antagonist
is studied in a hydrated bilayer of forty nine
l,2-di-myristoyl-sn-glycero-3-phosphorylcholine (DMPC) molecules using
molecular dynamics (MD) simulation technique.
- NADH
fluorophotography technique used in the study of nifedipine combined
with reperfusion in experimental myocardial infarction.
- The influence of
Nifedipine anf captropill on liver blood flow can be investigated using
echo-doppler technique.
- The applicability of
Gas-Liquid Chromatography technique is to measure plasma nifedipine
concentrations.
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