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General
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Metformin Hydrochloride is an anti-diabetic preparation.
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Metformin hydrochloride is a white, crystalline powder which is
odourless or almost odourless and hygroscopic.
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It is
freely soluble in water, slightly soluble in ethanol (96%), and
practically insoluble in chloroform and ether.
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The
chemical name for metformin hydrochloride is 1,1-dimethylbiguanide
hydrochloride.
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Metformin is an oral biguanide hypoglycaemic agent.
Process
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Metformin is excreted unchanged in the urine and does not undergo
hepatic metabolism.
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A
simple and rapid HPLC assay method for the estimation of metformin
in human plasma was developed and validated.
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Extended release (ER) formulation of metformin hydrochloride (HCl)
investigates the possibility for development of a direct compression
ER matrix tablet using hypromellose.
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The
synthesis, characterization and pharmacodynamic evaluation of the
copper [Cu2+] and nickel [Ni2+] complexes of metformin have been
studied.
Uses
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Metformin
may be used as initial treatment or in sulfonylurea failures either
alone or in combination with a sulfonylurea and other oral agents.
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Metformin
hydrochloride is an oral biguanidine, which reduces the elevated blood
glucose concentration in patients with diabetes but does not increase
insulin secretion.
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Metformin
hydrochloride is a high-dose drug widely used as an oral
anti-hyperglycemic agent.
Technology
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Small
size and improved release technology has evolved the therapy of
metformin. Thus, metformin still is used as a therapeutic agent of
first choice for monotherapy of the typical overweight patient.
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A
simple, rapid and precise method is developed for the quantitative
simultaneous determination of metformin hydrochloride and
rosiglitazone maleate in a combined pharmaceutical-dosage form.
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A high
performance reverse phase liquid chromatographic procedure is
developed for the Simultaneous estimation of Metformin Hydrochloride
and Pioglitazone hydrochloride in combined tablet dosage form.
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