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General
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Mebendazole or MBZ, marketed as Ovex, Vermox, Antiox or Pripsen, is a
benzimidazole drug that is used to treat infestations by worms including
pinworms, roundworms, tapeworms, hookworms, and whipworms.
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It
works by interfering with proteins in either the worm's intestine or
absorptive cells. This leads to the worm not being able to absorb sugars
which are essential for its survival.
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The
active ingredient in Pripsen powder is piperazine.
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Mebendazole is a white to slightly yellow powder with a molecular weight
of 295.29.
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It is
less than 0.05% soluble in water, dilute mineral acid solutions,
alcohol, ether and chloroform, but is soluble in formic acid.
Process
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Treatment of lung cancer cell lines with MZ caused mitotic arrest,
followed by apoptotic cell death with the feature of caspase activation
and cytochrome c release. MZ induces abnormal spindle formation in
mitotic cancer cells and enhances the depolymerization of tubulin.
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MZ
(methyl 5-benzoyl-2-benzimidazole-carbamate) is a broad-spectrum
anthelmintic drug that has been used to treat helminthic diseases in
humans all over the world.
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Mebendazole treatment had a downregulatory effect on the serum levels of
specific anti-Toxocara IgE antibodies, while those of total IgE
antibodies were not affected either with the use of diethylcarbamazine
or by mebendazole.
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Resistance has been widely reported in livestock parasites after
frequent de-worming, and although benzimidazole resistance has so far
not been conclusively demonstrated in human hookworms, drug resistance
may explain the apparent decline in mebendazole efficacy seen after
repeated mass treatment with mebendazole.
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Treatment of trichuriasis with mebendazole 500 mg yielded cure rates of
93.9 and 88.9% respectively.
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In
recent years, chemotherapy with mebendazole (MBZ), the
benzimidazole-carbamate compound that has been extensively used in the
treatment of helmintic infections, has also demonstrated in vitro
activity against Giardia duodenalis (G. duodenalis).
Techniques
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Recently, antihelmintic drugs, benzoimidazole carbamate derivatives
(albendazole and mebendazole) have been tried in hydatid disease, with
and without surgery.
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Even
though the mechanism of action is not known exactly, it probably
prevents the glucose uptake of the parasite and therefore production of
ATP.
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When
compared with albendazole, mebendazole has a decreased uptake in the
intestines, which means that mebendazole treatment is required for
longer with higher doses.
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