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General
- L-DOPA
(3,4-dihydroxy-L-phenylalanine) is an intermediate in dopamine
biosynthesis.
- In clinical
use, Levodopa (INN) is administered in the management of
Parkinson's disease.
- L-Dopa is
also used as a component in marine adhesives used by pelagic life.
- Once
levodopa has entered the central nervous system (CNS), it is
metabolized to dopamine by aromatic L-amino acid decarboxylase.
Process
- L-DOPA is
produced from the amino acid tyrosine by the enzyme tyrosine
hydroxylase.
Dopamine is formed by the decarboxylation of L-DOPA.
- L-DOPA can
be directly metabolized by catechol-O-methyl transferase (COMT)
to 3-O-methyldopa (3-OMD) and then further to vanillactic acid.
- Both
levodopa and its precursor amino acid L-tyrosine are precursors
to the biological pigment melanin.
- The enzyme
tyrosinase catalyzes the oxidation of L-dopa to the reactive
intermediate dopaquinone, which reacts further, eventually
leading to melanin oligomers.
Functions
- Effects
of Anonaine on Dopamine Biosynthesis and L-DOPA-Induced
Cytotoxicity in PC12 Cells.
-
Functions of Deep Brain Stimulation and L-dopa in Walking
Features of Parkinsonian Patients.
- Effect
of L-dopa on Nocturnal Prolactin Surges During Pseudopregnancy.
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Neurotrophic Effects of L-DOPA in Postnatal Midbrain Dopamine
Neuron/Cortical Astrocyte Cocultures
Report
- L-Dopa
Feeding Induces Body Growth and Reproductive Conditions in
Japanese Quail, Coturnix coturnix Japonica.
- The
influence of intermittent l-Dopa trearment on striatal
molecular markers in hempiparkinsonian rats.
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Production of 1-3:4, dihydroxyphenylalanine from tyrosine
from various sources detailed study.
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Assessment details of pharmacokinetic interaction of L-Dopa
and benserazide.
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