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General
- Inositol, (of
which the most prominent naturally occurring form is myo-inositol,
cis-1,2,3,5-trans-4,6-cyclohexanehexol), is a carbocyclic polyol that
plays an important role as the structural basis for a number of
secondary messengers in eukaryotic cells.
- It including
inositol phosphates, phosphatidylinositol (PI) and phosphatidylinositol
phosphate (PIP) lipids.
- It is found
in many foods, in particular, in cereals with high bran content, nuts,
beans, and fruit, especially cantaloupe melons and oranges. Inositol is
not considered a vitamin itself because it can be synthesised by the
body.
Process
- Extracts of
immature kernels of Zea mays catalysed the synthesis of indol-3-
ylacetyl-myo-inositol galactoside from indol-3-ylacetyl-myo-inositol and
UDP-galactose.
- The product of the
reaction contained radioactivity from UDP-[U-'4C]galactose and was
identified as indol-3-ylacetylmyo-inositol galactoside by gas
chromatography-mass spectrometry.
- Therefore a
UDP-galactose :indol-3-ylacetyl-myo-inositol galactosyltransferase
(indol-3-ylacetylmyo-inositol galactoside synthase) is present in
developing kernels of Zea mays.
Technology
- The enzyme
inositol oxygenase (myo-inositol : oxygen oxidoreductase; is a
monooxygenase that converts inositol into glucuronic acid in the
presence of molecular oxygen.
- Myo-inositol and
several other polyols in cerebrospinal fluid (CSF) and plasma from 10 AD
subjects and 10 healthy age-matched controls by using a gas
chromatographic-mass spectrometric technique.
- A myo-inositol
transport mutant was isolated from UV-mutagenized S. cerevisiae cells
using the replica-printing technique.
- There is a paucity
of data on the way (cAMP, inositol), qualitatively or quantitatively,
altered in heart failure (HF).
- These studies were
performed separately on animal models, but no study checked cAMP and
inositol changes in the same animal model simultaneously.
Market
- Currently there
are 11 active producers of inositol in China, and most of them are
distributed in North China.
- China is a large
producing country of inositol in the world, about 80% of whose output
was exported to overseas market.
- Thus
overseas demand of inositol has an important impact on Chinese inositol
industry.
Application
- Pig feed is mainly
based on cereals where phosphorus (P) is mostly present in inositol
hexaphosphate (IP6), which is not readily available to monogastric
animals.
- Inositol
phosphate-containing molecules play an important role in a broad range
of cellular processes.
- Inositol
5-phosphatases participate in the regulation of these signaling
molecules.
- Inositol is a
simple isomer of glucose that is a key metabolic precursor in the
phosphatidylinositol cycle.
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