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• Glibenclamide, also known as glyburide, is an anti-diabetic drug in a class of medications known as sulfonylureas, used in the treatment of type II diabetes.
• Glyburide is in a class of drugs called sulfonylureas.
• It is used to help control blood sugar levels.
• Treatment with glyburide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin.

Process

• The drug works by inhibiting ATP-sensitive potassium channels in pancreatic beta cells.
• This inhibition causes cell membrane depolarization, opening of voltage-dependent calcium channels, thus triggering an increase in intracellular calcium into the beta cell which stimulates insulin release.

Technology

• The whole-cell patch-clamp technique was used in adult mouse ventricular myocytes at 22°C to study the transient outward current and its sensitivity to the antimycotics miconazole and clotrimazole, as well as to glybenclamide.
• Inhibition of ATP-sensitive K+ channels and the resultant depolarization are essentially involved in the mechanisms by which antidiabetic sulfonylureas drugs , repaglinide, and nateglinide1. stimulate insulin secretion from pancreatic b-cells.

Report

• To identify among women with gestational diabetes mellitus the patient characteristics that predict treatment failure with glyburide.
• Glyburide was more likely to fail in women diagnosed earlier in pregnancy, of older age and multi parity, and with higher fasting glucoses, suggesting that earlier glucose intolerance and a reduced capacity to respond to an insulin secretagogue may distinguish this group.