General
- Colchicum plant has a
large, ovate, solid, fleshy corm (tuber, according to some authors). The
leaves are dark-green, very smooth, obtuse, above a foot long, 1 1/2
inches broad, keeled, and produced in the spring along with the
capsules. The flowers are several, radical, leafless, and bright purple,
with a long, white tube appearing in the autumn without the leaves.
- The capsules 3 and
distinct, though forming together a single, oblong, elliptical fruit,
with intermediate fissures. The seeds are whitish and polished. Gloriosa
superba belongs to Colchicaceae family and it occurs naturally in
Africa, in India, and southeastern Asia, and is nowadays distributed
wide throughout the tropics, and worldwide as a pot plant.
- Colchicum root is
About 25 Mm. (1 inch) long, ovoid, flattish, and with a groove on one
side; externally brownish and wrinkled; internally white and solid;
often in transverse slices, reniform in shape, and, breaking with a
short, mealy fracture; inodorous; taste sweetish, bitter, and somewhat
acrid. Colchicum seed is Subglobular, about 2 Mm. ( 1/12 inch) thick,
very slightly pointed at the hilum; reddish-brown, finely pitted,
internally whitish; very hard and tough; inodorous; taste bitter and
somewhat acrid.
Extraction &
Growth
- Three Different
Methods for extraction of Colchicine have been studied, and it was found
that extraction with petroleum ether and chloroform is the best and most
reliable method. Colchicine is readily converted into the corresponding
hydroxymethylene derivative, colchiceine, by hydrolysis of the
methoxymethylene group in dilute acid solution. The solution containing
colchicine and colchiceine is extracted by shaking with three separate
lots of 3 ml. chloroform.
- Gloriosa superba L.
is a semi-woody herbaceous branched climber, reaching approximately 5
meters in height. It is also planted outdoors in the southern United
States. In cool temperate countries, it is treated as a greenhouse or
conservatory plant. In Bangladesh the plant is naturally found to grow
in Sal Forests of Dhaka and Gazipur districts. G. superba is considered
to be a herbaceous plant, little attention is given towards its
propagation and culture. It is commonly grown from seeds and tubers.
Application &
Technology
- The daily application
of colchicine is the standard therapy for prophylaxis of attacks and
amyloid deposition in familial Mediterranean fever. Colchicine is the
standard drug used to prevent febrile attacks and amyloidosis. We (an
interdisciplinary group of German and Turkish physicians) analyzed the
data and graded the evidence on the efficacy and adverse effects of
colchicine therapy in children and adolescents with FMF.
- Rapid toxicity
technologies use various biological organisms and chemical reactions to
indicate the presence of toxic contaminants. The toxic contaminants are
indicated by a change or appearance of color or a change in intensity.
As part of this verification test, ToxScreen-II was subjected to various
concentrations of contaminants such as industrial chemicals, pesticides,
rodenticides, pharmaceuticals, nerve agents, and biological toxins.
Report
- A subsequent review
of medical records revealed that a third death from colchicine toxicity
in a patient treated at the Oregon clinic also occurred in March and
likely was associated with the same compounding error. These deaths
highlight the potential risk from use of IV colchicine for back pain and
the possibly fatal consequences of measuring errors in compounding
pharmacy products.
- World demand for
colchicine is still appreciably high today for the treatment of gout and
it is sourced as a raw material for the manufacture of a drug widely
used in Europe for the treatment of spasticity and muscular
contractures. Colchicine is also known as an antimitotic agent and its
citotoxic properties were discovered in 1889 by the Italian scientist
Pernice.
Entrepreneur who want the
informations on "General Information, Extraction, Growth, Technology, Applications, Patent,
Projects, Properties & Functions, Toxicity, Consultants, Company Profiles,
Reports, Market, Suppliers & Buyers" can
Email as to
informer@eth.net,
primaryinfo@gmail.com
|
Extraction,
Growth, Technology, Applications, Patent, Consultants, Company Profiles,
Reports, Market
Primary Information
Services