Calcitonin-General, Extraction and purification, Company Profiles, Products, Material Safety Data Sheet, Market, Report, Functions, Buyers, Suppliers, Technology, Application, Patent, Guides, Consultants

General

Calcitonin is a 32 amino acid polypeptide hormone that is produced in humans primarily by the Parafollicular cells of the thyroid, and in many other animals in the ultimobranchial body.
Calcitonin is a hormone known to participate in calcium and phosphorus metabolism. In mammals, the major source of calcitonin is from the parafollicular or C cells in the thyroid gland, but it is also synthesized in a wide variety of other tissues, including the lung and intestinal tract. In birds, fish and amphibians, calcitonin is secreted from the ultimobrachial glands.
Calcitonin is an endogenous hormone that has been identified in different forms in more than 15 species of mammals, birds, amphibians and fish, and even in unicellular organisms.

Technology

To assess the functional role of calcitonin during implantation, we recently employed an antisense technology to regulate calcitonin gene expression in rat uterus.

Calcitonin gene related peptide (CGRP) related molecules were purified from sardine hydrolysates prepared using 0.1% alcalase and two hours of hydrolysis. Gel exclusion chromatography and HPLC performed purification of these molecules.

Application

Calcitonin is considered the drug of choice for the management of acute pain associated with vertebral fracture secondary to osteoporosis.

Calcitonin is a man-made hormone that works by slowing bone loss and maintaining normal calcium levels in the blood. It may also help to reduce bone pain in people who have Paget's disease.

Salmon calcitonin nasal spray at a dose of 200 IU dady significantly reduces the risk of new vertebral fractures in postmenopausal women with osteoporosis.

Market

A joint venture between US-based Unigene Laboratories and China's Shijiazhuang Pharmaceutical Group will begin selling injectable calcitonin in China for the treatment of osteoporosis.

The osteoporosis pharmaceutical market is currently $7 billion and is expected to grow to $14 billion by 2011. According to IMS, a market research firm, worldwide sales of an existing Calcitonin-Salmon Nasal Spray were approximately $389 million in current year, of which the U.S. accounts for an estimated $240 million.

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