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General
- Bronopol (INN) is a
highly active antimicrobial chemical compound whose chemical formula is
2-bromo-2-nitropropane-1,3-diol.
- Bronopol was invented
by The Boots Company PLC, Nottingham, England.
- Bronopol is supplied
as crystals or crystalline powder.
- Bronopol is readily
soluble in water although the dissolution process is endothermic.
- Bronopol is also a
formaldehyde releaser.
- Bronopol is easily
biodegradable.
Process
- Bronopol is effective
in pH 5-8 and presumably more so in alkaline environments where it is
also more rapidly degraded.
- A contaminant is
formed in the synthesis of Bronopol and is a known formaldehyde former.
- Bronopol,
2-bromo-2-nitroethanol and bromonitromethane were measured using HPLC
and electrochemical detectors.
- Bronopol undergoes
rapid hydrolysis as well as biodegradation, which may explain its
absence in the environmental matrix samples.
- A screening process
were made on biocides for seawater thin film membrane compatibility and
biocidal efficacy. The screening studies resulted in three promising
biocides: Minnacare, Bronopol, and sodium bisulfite.
Application
- Bronopol was
subsequently taken up as an effective antimicrobial in many industrial
environments such as paper mills, oil exploration and production
facilities, as well as cooling water disinfection plants.
- Bronopol is used in
consumer products as an effective preservative agent, as well as a wide
variety of industrial applications.
- Bronopol is readily
soluble in water although the dissolution process is endothermic.
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2-Bromo-2-nitropropane-1,3-diol (bronopol) has a broad spectrum of
antibacterial activity (12) and is widely used, at concentrations of up
to 0.1% (wt/vol), as a preservative for pharmaceutical and cosmetic
products.
Report
- Biocides introduced
to the market after May 2000 have to be identified to the EC prior to
authorisation.
- A research analyst
suggested that there is a strong potential for growth of the biocides
market in the plastics industry.
- Bronopol is
officially classified in the EU Council Directive - 67/548/EEC as
harmful, irritant and dangerous for the environment.
- Using bronopol
microtabs versus potassium dichromate will cost the laboratory
approximately $160 per month more since bronopol is more expensive than
potassium dichromate.
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