- BOTOX® is a drug known
most widely for its ability to temporarily smooth out facial wrinkles,
though it also has several medical applications. Both its cosmetic and
medical applications relate to Botox’s ability to block muscle
contractions.
- Botox belongs to a
class of products known as biologics—physiologically active substances
produced naturally by organisms (in this case bacteria) or synthetically
in the laboratory
- Botulinum toxin is a
neurotoxin protein produced by the bacterium Clostridium botulinum. It
is one of the most poisonous naturally occurring substances in the
world, and it is the most toxic protein. It is sold commercially under
the brand names Botox and Dysport for this purpose. The terms Botox and
Dysport are trade names and are not used generically to describe the
neurotoxins produced by the clostridia species.
- Botox blocks signals
from the nerves to the muscles. The injected muscle can no longer
contract, which causes the wrinkles to relax and soften. It is most
often used on forehead lines, crow's feet (lines around the eye) and
frown lines. Wrinkles caused by sun damage and gravity will not respond
to Botox.
- The market trend for
BOTOX® injection rates are up 31%, while alternatives such as chemical
peels are down 31%, and collagen injections, once very popular, have
dropped by 46%. The consumer can pay $5000 for a facelift to remove
lines and wrinkles now, or as an alternative can undertake twelve BOTOX®
injections over time.
- Consumers are avid for
non-invasive alternatives to Botox and cosmetic surgery, driving a
"cosmeceuticals" market destined to grow 8.5% to $5.1 billion by
2007.
- The increase in
popularity of nonsurgical procedures like Botox injections for wrinkles
is due to people becoming satisfied with less drastic measures to remove
wrinkles. From 2002 to 2003, the demand for Botox injections for
wrinkles resulted in a 153 percent increase, accounting for more than
887,000 procedures.
- Costs for botox can
vary significantly based on how much an individual needs and wishes to
get, and based on who is administering it. Some skin care centers
advertise low prices for botox on a "cost per area" basis, advertising
prices of $200-$300 for one area.
- The first rule of Botox
safety is that the procedure is perform only by a board certified
plastic surgeon who has experience with all aspects of the
Procedure.
- Botox is approved by
the U.S. Food and Drug Administration (FDA) to treat several medical
conditions (its “therapeutic” applications):
• Cervical Dystonia –
involuntary movement and prolonged muscle contraction of the neck, •
Blepharospasm – involuntary forcible closure of the eyelids, •
Strabismus – crossed eyes, • Hyperhidrosis – excessive sweating, •
Dynamic muscle contracture in pediatric cerebral palsy patients
(approved as an orphan drug) – an abnormality of motor function usually
acquired at a young age.
- Botox has been approved
for cosmetic applications in the following countries: Canada (2001), New
Zealand (2001), United States (2002), Australia (2002), Switzerland
(2002), Taiwan (2002), Singapore (2002), and France.
- Botulinum toxin type A,
brand name Botox®, is an effective preventative therapy for headache and
Migraine pain in chronic sufferers, according to the largest study
performed to date, presented at the 45th Annual Scientific Meeting of
the American Headache Society (AHS) in June.
-
Botox is approved by
the Food and Drug Administration (FDA) for treatment of blepharospasm
(eyelid spasm), strabismus (crossed eyes), cervical dystonia (painful
neck spasms) and wrinkles between the eyebrows, but not for headache or
Migraine. Studies to obtain FDA approval for that use are
proceeding.
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