|
General
- Aciclovir (INN)or
acyclovir (USAN, former BAN), chemical name acycloguanosine, is a
guanine analogue antiviral drug.
- Aciclovir was seen as
the start of a new era in antiviral therapy.
- Aciclovir differs
from previous nucleoside analogues in that it contains only a partial
nucleoside structure.
- Acyclovir is poorly
water soluble and has poor oral bioavailability.
- Acyclovir is
available with a prescription under the brand name Zovirax.
- Acyclovir is
prescribed as a cream or ointment (topical use), oral tablets, or
intravenous liquid.
Process
- Acyclovir is highly
selective due to its affinity for the enzyme thymidine kinase (TK)
encoded by HSV and VZV. This viral enzyme converts acyclovir into
acyclovir monophosphate, a nucleotide analogue.
- The comparability of
systemic aciclovir exposure at steady state in immunocompromised
patients has been evaluated.
- Two common hydrolytic
enzymes were used as the catalysts for the transesterification of
acyclovir.
- The antiviral action
of acyclovir involves its enzymatic conversion into the triphosphate of
acycloguanosine 9-[(2-hydroxyethoxy)methyl]guanine}.
- Acyclovir
{9-[(2-hydroxyethoxy)methyl]guanine} is a synthetic purine nucleoside
analog derived from guanine.
Application
- Acylovir is indicated
for the treatment of HSV and VZV infections.
- Taking acyclovir with
food may decrease stomach upset.
- Acyclovir is used to
treat infections caused by herpes viruses.
- Acyclovir is a purine
nucleoside analogue with effects against human herpesvirus infections.
- Antiviral nucleoside
acyclovir acts as a potential drug candidate for improving antiviral
efficacy against herpetic epithelial and stromal keratitis.
- The use of acyclovir
(ACV) has become an established part of clinical practice.
Technology
- HPLC technique is
used for the determination of guanine nucleoside derivative acyclovir in
serum, saliva and urine.
- Inderting Acyclovir
twice a day by melt extrusion technique helps to improve patient
complience using hydroxypropylcellulose as thermoplastic polymer.
- Suppression and
reactivation of viral replication were evaluated by functional and
molecular techniques.
- The effect of solvent
polarity on the keto–enol tautomerism of N- and O-acetylated acyclovir
derivatives has been studied through different spectroscopic technique.
Entrepreneur who wants the
information on "General Information, Process,
Technology, Applications, Patent, Consultants, Product, Company Profiles, Reports,
MSDS, Function" can email us to
informer@eth.net
,
primaryinfo@gmail.com |
Process,
Technology, Applications, Function, MSDS, Patent, Consultants, Product,
Company Profiles, Reports
