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Information @ a Glance

General

  • Umezawa and coworkers discovered kasugamycin as a bactericidal and fungicidal metabolite of Streptomyces kasugaensis.
  • Kasugamycin (Ksg) is an aminoglycoside antibiotic that was originally isolated in 1965, from Streptomyces kasugaensis
  • Kasugamycin is recommended for the control of rice blast (P. oryzae; perfect stage M. grisea) in rice, leaf spot in sugar beet and celery (Cercospora spp.), bacterial disease in rice and vegetables and scab (Venturia spp.) in apples and pears.
  • Kasugamycin acts as an inhibitor of protein biosynthesis in microorganisms.
  • Kasugamycin is less phytotoxic than blasticidin-S with a wider margin between curative and phytoxtoxic concentrations.
  • Kasugamycin is mainly applied as a dust and can also be used as a seed treatment as a wettable powder.

Uses

  • Anti-biotic used for clinically bacterial infection, especially to bacillus coli and bacillus pyocyaneus.
  • Agricultural fungicide used to treat rice blast, cucumber anthracnose, cucumber angular leaf spot, tomato gray mold, cabbage black rot and citrus gummosis 
  • Control of fungal and bacterial diseases affecting rice, vegetables and fruit.
  • In sugar beet, it controls Cercospora beticola, at 80-100 g/ha.
  • On rice, it controls diseases caused by Pyricularia oryzae and Burkholderia glumae (bacterial grain rot), with ground and aerial applications, at 20-30 g/ha, and seedling diseases caused by various bacterial pathogens, at 0.3-0.6 g/box.

Report

  • Research shows that Kasugamycin can associate with the 30s ribosomal subunit, which results in the indirect inhibition of the P-site tRNA binding, and blocks protein synthesis.
  • Kasugamycin was effective against fire blight caused by isolates of E. amylovora that were streptomycin/oxytetracycline-sensitive or -resistant.
  • Kasugamycin efficacy equivalent or better than terramycin or streptomycin.
  • Kasugamycin resistant mutants from a large number of conidia of finger millet isolates, and proved that resistance of a certain mutant was controlled by a single major gene. In the present paper, further studies on genetical control of kasugamycin resistance in P. oryzae will be presented with special reference to identification of three different resistance loci.

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