General
- Iprodione is a
non-systemic fungicide, widely used in agriculture.
- Iprodione is a
solid (m.p. 133ºC) of low vapour pressure (5 x 10-7 at Pa 250C), with
log P Kow of 3.0.
- It is slowly
hydrolyzed at pH 5 and progressively more rapidly at higher pH values.
- It is degraded
only slowly by photolysis.
- Its water
solubility is not pH dependent and iprodione has no acidic or basic
properties.
- Used to control Botrytis, Monilia,
Sclerotinia, Alternaria, Corticium, Fusarium, Helminthosporium, Phoma,
Rhizoctonia, Typhula spp., etc
- It can also be used as a post-harvest
dip, as a seed treatment, or as a dip or spray at planting.
First
Aid Measures
- In case of contact, immediately
flush eyes with copius amounts of water for atleast 15 minutes.
Immediately wash skin with soap and copius amounts of water.
- If inhaled, remove to fresh
air.If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. If swallowed, wash out mouth with water
provided person is conscious.
- Call a physician.
- Wash contaminated clothing before
reuse.
Report
- Iprodione has been evaluated for
toxicology and residues by the JMPR on a number of occasions and has
been reviewed by the US EPA and the EU.
- Experimental studies with mice
have indicated that exposure to iprodione at dose levels 5 to 15
folds greater than the LOAEL for liver injury, induces microsomal
enzyme activities, hepatocyte proliferation, hepatomegaly,
centrilobular hypertrophy, diffuse hypertrophy, and an increase in
lauric acid hydroxylation.
- Data obtained from the above
experiment showed that iprodione is able to induce a significant
number of stress genes in HepG2 (human liver carcinoma cells).
Toxicity
- Iprodione is not acutely toxic
via the oral, dermal, inhalation, or ocular routes of exposure.
- In an acute oral toxicity study
with rats, the LD50 was 4468 mg/kg, which is toxicity category III.
- The LD50 in an acute dermal
toxicity study with rabbits was found to be greater than 2000 mg/kg.
This is toxicity category III.
- In an acute inhalation toxicity
study with rats, the LC50 was greater than 5.16 mg/L for 4 hours.
This is toxicity category IV.
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