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- Hydromorphone, a more
common synonym for dihydromorphinone, commonly a hydrochloride is a
very potent centrally-acting analgesic drug.
- Hydromorphone (Dilaudid®)
belongs to a class of drugs called opioids which includes morphine.
- Hydromorphone may
cause constipation, pupillary constriction, urinary retention,
nausea, vomiting and respiratory depression.
- Hydromorphone is
legally manufactured and distributed in the United States.
- It is considered the
strongest of the antitussive drugs, and was developed shortly after
diacetylmorphine (heroin) was removed from clinical use.
- Hydromorphone is used
to relieve moderate to severe pain and severe, painful dry coughing.
- Hydromorphone was
first synthesized and researched in Germany.
- Hydromorphone is known
in various countries around the world by the trade names Hydal,
Dimorphone, Sophidone LP, Dilaudid, Hydrostat, Hydromorfan,
Hydromorphan, Hymorphan, Laudicon, Hymorphan, Opidol, Palladone, and
others.
- Hydromorphone
hydrochloride (anhydrous) is the salt used in virtually all
hydromorphone products and in prescription compounding at this time.
- Although hydromorphone
is a very good pain killer it is not helpful for all types of pain.
- A GC/MS method
suitable to conduct practical toxicological analyses of unspecified
opiates including hydrocodone or hydromorphone. Silylation can be a
convenient reaction to derivatize unknown analytes in toxicological
samples.
- Patient-controlled
analgesia (PCA) is a widely used delivery system for intravenous
(IV) administration of opioids during acute post-operative pain
management. Various opioids have been used for IV PCA including
morphine, meperidine, hydromorphone, and fentanyl.
- The morphine alkaloid
hydromorphone (dihydromorphinone) was identified as an intermediary
metabolite in the degradation of morphine by Pseudomonas putida M10.
- Hydromorphone can be
used as a premedication, alone or in combination with tranquilizers
or sedatives; as part of an induction regime for high-risk patients;
and as an analgesic in the perianesthetic period.
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