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- Etoposide is a
chemotherapy drug that is usually given to treat lung, ovarian and
testicular cancer.
- Etoposide is a
colourless fluid. It is also available as 50mg and 100mg pale pink
capsules.
- Etoposide can cause a
rash, which may be itchy.
- Etoposide is one of
the most widely used antineoplastics.
- Etoposide is often
incorrectly referred to as a topoisomerase inhibitor in order to
avoid using the term "poison" in a clinical setting.
- Etoposide forms a
ternary complex with DNA and the topoisomerase II enzyme, preventing
re-ligation of the DNA strands.
- Etoposide must not be
given by intra-cavity injection.
- Etoposide is
contraindicated in patients with severe hepatic and/or renal
dysfunction or in those patients who have demonstrated
hypersensitivity to etoposide, podophyllotoxin, podophyllotoxin
derivatives or any other component of this preparation.
- Etoposide is given by
an intravenous (IV) infusion (a slow drip through a needle into your
port or through a vein in your arm or hand) or infused
intraperitoneal (IP; into your abdominal cavity by a special port
placed in your abdominal wall), and it is also available in a pill
form.
- Etoposide or etoposide
phosphate may be used intravenously as a component of various
chemotherapeutic regimens for the treatment of refractory testicular
tumours in patients who have already received appropriate surgery,
chemotherapy, and radiation therapy.
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Injections, Uses,
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