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Information @ a Glance

  • Cytokines are small cell-signaling protein molecules that are secreted by the glial cells of the nervous system and by numerous cells of the immune system and are a category of signaling molecules used extensively in intercellular communication.
  • Cytokines can be classified as proteins, peptides, or glycoproteins; the term "cytokine" encompasses a large and diverse family of regulators produced throughout the body by cells of diverse embryological origin.
  • Cytokines have been classed as lymphokines, interleukins, and chemokines, based on their presumed function, cell of secretion, or target of action.
  • Cytokines are small secreted proteins which mediate and regulate immunity, inflammation, and hematopoiesis.
  • Cytokines regulate the intensity and duration of the immune response by stimulating or inhibiting the activation, proliferation, and/or differentiation of various cells and by regulating their secretion of Abs or other cytokines.
  • Cytokines/immunocytokines, were initially used to separate the immunomodulatory proteins, also called immunotransmitters, from other growth factors that modulate proliferation and bioactivities of non-immune cells.
  • Cytokines play an important role in the understanding and treatment of diseases in many medical specialties.
  • Cytokines are highly pharmacologically active and thus may be effective agents for modifying biological responses.
  • In Previous Years, US sales of cytokines grew to $3.8 billion, largely driven by steep price increases.
  • Four kinds of cytokines are currently available: interferon (IFN)-α, IFN-β, IFN-γ and the interleukins.
    IFN-β brands, indicated for multiple sclerosis (MS), are the biggest sellers in the cytokines markets, constituting 76% of the total sales of this sector.
  • Cytokines and growth factor related products in the multiplexed bead array market may represent approximately 60-70% of product revenues.
  • Recently, fluorescent anti-cytokine and anti-chemokine monoclonal antibodies have become very useful for the intracellular staining and multiparameter flow cytometric analysis of individual cytokine-producing cells within mixed cell populations.

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