General
- Cyphenothrin is a
pyrethroid chemical used as an insecticide.
- Cyphenothrin is the BSI common name for (RS)-α-cyano-3-phenoxybenzyl
(IRS)-cis,trans-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate(IUPAC).
-
Physical Properties : Cyphenothrin is a vicous, yellowish liquid
with a molecular mass of 375.45,relative density of 1.08. Cyphenothrin has a water solubility of <10
ppb.
-
Stability : The
compound was reported to be stable in the diet over a period of 4 weeks
when kept under cold (4 °C) and light -shielded conditions, and under
study conditions (23±2°C,
55±10°C
relative humidity).
- Pyrethroid
acts upon both the peripheral and central nervous system of the insect
to stimulate the nerve cells to produce repetitive discharges and
eventually cause paralysis.
Toxicity
- Cyphenothrin was
generally rapidly absorbed, metabolised and excreted in the rat.
-
The acute toxicity data
indicate that cyphenothrin is moderately toxic (Category II) via
the oral route of exposure, slightly toxic (Category III) via the
inhalation route of exposure, and has low toxicity (Category IV)via the
dermal route of exposure. Cyphenothrin is non-irritating to the eye
(Category IV) and is neither a dermal irritant nor a skin sensitizer.
- Cyphenothrin reached
their peaks after oral dosing within 1 to 2 hours. Level of
radiolabel in brain tissue were much lower than those in blood and
liver.
- Cyphenothrin was fed
to male and female fischer (F-344) rats (80/sex/dose for two years at
dietary levels of 0, 100, 300, or 1000 ppm. average dosages for
males and females, respectively, were 4.80 and 5.89 mg/kg/d for
the 100 ppm groups; 14.49 and 17.77 mg/kg/day for the 300 ppm
groups; 48.16 and 58.52 mg/kg/day for the 1000 ppm groups.
Uses
- uses - control of houseflies, midges and cockroaches in
household use, public health, and industrial use. Also controls insects
which attack wood and fabric.
- use pattern - Cyphenothrin is formulated as a liquid. Squeeze-on
product for the control of fleas,ticks and other
Application
-
Cyphenothrin EC, a new
synthetic pyrethroid was evaluated in cookhouses in an urban area, with
the aim of exploring alternate control option against the German
cockroach Blatella germanica.
-
Cyphenothrin @ 50 mg a.i./m2
was sprayed in selected cookhouses at the infested sites and potential
harbourages by compression pneumatic sprayer.
-
A very high cockroach kill
was observed within 24 h of cyphenothrin treatment of the infested
cookhouses;
the weekly monitoring showed 86.3% reduction in cockroach infestation in
the treatment site-1 by first week post-treatment.
-
Cyphenothrin brought about
95 to 97.5% reduction in cockroach infestation by the end of six weeks
post-treatment.
-
The duration of effective
control offered by this insecticide against German cockroaches though is
low (6 weeks) as compared to the reported efficacy of up to 90 days with
fipronil gel 0.05%, however, the initial control offered by cyphenothrin
in the first week posttreatment (86 to 96%) is comparable to fipronil
gel (89%) in studies conducted under similar settings.
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