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Introduction

• Coughing is one of the most recognizable symptoms of illness.

• It can also be one of the most annoying. Frequent coughing can irritate the throat, make the ribs sore and even be embarrassing.

• Coughing related to upper respiratory tract infections is one of the most frequent reasons for ambulatory visits to health-care providers.

• If you have a dry, hacking cough, dextromethorphan may give you relief. Generally, these cough syrups and cough medicines are not used to suppress a cough where you cough up mucus.

• Hydrocodone is a semi-synthetic opiate and is considered to have the strongest effect in blocking the cough reflex. Like all narcotics, it can cause drowsiness and decrease respiratory drive.

• In addition, chronic use can lead to addiction. It is commonly combined with medications such as acetaminophen and homatropine to discourage overuse.

• Dextromethorphan is a non-opiate antitussive medication that has been available over the counter since 1958. It does not have the side effects of sedation or respiratory suppression. Its effectiveness has been debated, and it is generally not considered effective in children.

• Three types of cough medicines are available OTC for the temporary relief of cough due to a cold or bronchitis. These cough medicines include cough suppressants, oral expectorants, and topical (externally applied) drugs.

Technology

• A HPLC method for rapid and simultaneous quantification of Terbutaline sulphate, Bromhexine Hcl and Guaifenesin in a cough syrup formulation.

Report

• Law enforcement authorities and treatment providers primarily in Houston and San Antonio (TX), Alabama, and other areas of the southern United States, are reporting that abuse of a readily available prescription-strength cough syrup containing promethazine (an antihistamine antiemetic) and codeine (a prescription opioid) appears to be increasing.

• Fifty patients of either sex aged 15 - 65 years entered the study to test the efficacy and tolerability of a herbal preparation known as Khasceeze-SF Cough Syrup. They were studied for cough and related symptoms such as sore throat, sneezing, breathlessness and fever.

• Substantial improvement, i.e., excellent to good response, in relief of cough and other symptoms was noted over 84% out of 50 patients and fair response in 11.64%. Only 4.10% patients showed poor relief in symptoms hence suggested Khasceeze-SF Cough Syrup facilitated a healing touch to the diseased bronchial tree and helps alleviate the cough of any aetiology.

• No drowsiness, irritability, or dryness in mouth was seen with Khasceeze-SF Cough Syrup.

• Many infections are treatable with drugs/antibiotics. Cough syrups that contain glyceryl guaiacolate can improve secretion of cervical mucus, in some cases, where trauma has decreased the production of cervical mucus.

• Prescription-strength promethazine and codeine cough syrup is legitimately used to treat
  allergies, bronchitis, the common cold, influenza, and sinusitis.

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