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Calcium Phosphate Cement
Process, Patent,
Properties, Technology, Application, Functions, Companies in the field, Reports
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General
Information
- Calcium phosphate
cements (CPCs) typically harden following the combination of a
powder and an aqueous liquid.
- Calcium phosphate
cements are the emerging class of bone substitute materials.
- The principle of CPCs
is the cementing action of acidic and basic calcium phosphate
compounds on wetting with an aqueous medium.
- It has been nearly 30
years since LeGeros and Brown and Chow first developed calcium
phosphate cements (CPCs) for biomedical applications.
- Of these different
CPC, the type of precipitation furnishes a classification of the
cement type: brushite, hydroxyapatite, calcium-deficient
hydroxyapatite, or amorphous calcium phosphate.
Process
- CPC are made of
one or several calcium phosphate (CaP) powders and an aqueous
solution. CPCs belong to the category of the low-temperature
CaPs that are obtained by precipitation from an aqueous solution
at or around room temperature.
- Calcium phosphate
cements (CPCs) were prepared using mixtures of tetracalcium
phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA), with
TTCP/ DCPA molar ratios of 1/1, 1/2, or 1/3, with the powder and
water as the liquid.
Uses
- Calcium
phosphate cements control bleeding and are safe to use in
osteoporotic sternums during open heart surgery.
- Calcium
phosphate cement (CPC) hardens in situ to form
hydroxyapatite and has been used in dental and craniofacial
restorative applications.
- In dentistry
calcium phosphate cements play a secondary role at the
moment, although they often have excellent bone repair
properties.
- CPC’s have
been widely used as a bone tissue engineering scaffold
material due to its excellent osteoconductivity, however, in
vivo resorption and tissue in growth is slow.
Report
- Another
calcium phosphate cement is also now available on the
market in Europe: Calcibon® (Biomet-Merck).
- Callos is
a next generation calcium phosphate cement indicated for
filling bony defects in cancellous bone.
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Approximately there are 300,000 surgeries which use
calcium phosphate bone cement for fracture fixation in
the U.S annually.
- The
development of calcium phosphate cements (CPC) started
almost three decades ago with the formulation of in
situ-setting calcium phosphate pastes for dental repair
and restoration applications.
- The
most recent calcium phosphate cement to be introduced to
the market is a-BSM from Etex Corp.
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Primary Information Services
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