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General
- Salbutamol is an
inhaled medication commonly used in quick-relief inhalers and
nebulizers.
- People with asthma
and chronic obstructive pulmonary disease (COPD) are often
prescribed salbutamol to help control their disease.
- Salbutamol working by
opening up the lungs and helping you to breathe when you are having
an asthma attack or other difficulty breathing.
- This medicine is also
useful for the prevention of exercise-induced bronchospasm, as well
as indicated in hyperkalemia, especially in patients with renal
failure.
Uses
- Salbutamol is
typically used to treat bronchospasm (due to either asthma or
exercise) as well as chronic obstructive pulmonary disease.
- Other uses include in
cystic fibrosis, along with ipratropium bromide, acetylcysteine, and
pulmozyme and subtypes of congenital myasthenic syndromes associated
to mutations in Dok-7.
- As a β2-agonist,
salbutamol also finds use in obstetrics. Intravenous salbutamol can
be used as a tocolytic to relax the uterine smooth muscle to delay
premature labor.
- While preferred over
agents such as atosiban and ritodrine, its role has largely been
replaced by the calcium-channel blocker nifedipine, which is more
effective, better tolerated and orally administered.
Market
-
In 1969, Allen & Hanburys (part of the Glaxo Group, now
GlaxoSmithKline) launched the highly successful asthma drug
salbutamol.
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Marketed just three years after its synthesis, salbutamol is still
on the market, sold as Ventolin and Proventil.
-
Salbutamol was one of the earliest drugs developed by rational
design. At the time there were no models of the
 -receptors
to guide the work; the human -receptor
was not characterized until the 1990s.
Research
- Based on
Preformulation studies different batches of Salbutamol sulphate were
prepared using Xanthan gum, carbopol and ethyl cellulose chosen for
their different hydrophilic properties to calculate the suatained
release properties.
- Analysis of
Salbutamol is done by UV visible spectrophometer using
wavelength 276nm.
- Results of in-vitro
swelling study indicate that the formulation F6 was having
considerable swelling index.
- Visual observation
show that all the coated particles preserve their structural
integrity whereas
uncoated salbutamol sulphate particles are unstable at 65% of
relative humidity
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