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Niacinamide (Vitamin B3) is utilized in numerous topical cosmetic
products to provide beneficial effects for a wide array of common skin
problems such as those associated with aging and photo aging, e.g.,
dryness, red blotchiness, hyper pigmentation, texture problems and fine
lines/wrinkles .
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A general mechanism for niacinamide is as a precursor to the important
cofactors nicotinamide adenine dinucleotide (NAD), its phosphate
derivative (NADP), and their reduced forms (NADH and NADPH).
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Large pharmacological doses of niacinamide were effective in relieving
the symptoms of anxiety.
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Niacinamide reduced lipogenesis in a dose-dependent manner, with
significant inhibitory
activity observed up to 4.0% (w/v) niacinamide.
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For example, at 1% niacinamide
lipogenesis was significantly reduced to 33% of control levels.
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Niacinamide has other possible biochemical properties (corrects
sub clinical pellagra, corrects vitamin B3 dependency, and favorably
modulates blood lactate) that may perhaps make it a more
effective agent than current contemporary medications for the treatment
of
anxiety disorders.
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Anti-inflammatory action affecting neutrophil chemotaxis has been
reported for niacinamide.
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Additionally, due to its inhibition of ADP-ribosylation, niacinamide
has been shown to suppress cytokinemediated induction of nitric
oxide synthase in a number of cells, thus effecting
interleukin-1-exposed chondrocytes, resulting in decreased
inflammation.
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Niacinamide inhibits free radical formation and facilitates
beta-cell regeneration in vivo
and in vitro.
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Nicotinamide has been reported to increase the endurance of mice.
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Biochemical data showing niacinamide to have both
benzodiazepine-like properties and the ability to increase serotonin
synthesis.
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