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Aristolochic
Acid
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- Aristolochic acids are
a family of carcinogenic, mutagenic, and nephrotoxic compounds
commonly found in the Aristolochiaceae family of plants, including
Aristolochia and Asarum, which are commonly used in Chinese herbal
medicine.
- Aristolochic acid I is
the most abundant of the aristolochic acids and is found in almost
all Aristolochia species.
- Aristolochic acids are
slightly soluble in water, have a melting point between 281 and 286
degrees Celsius, and have a bitter flavor.
- Aristolochic acids may
be a causative agent in Balkan nephropathy.
- Plants containing
aristolochic acids are often used as herbal medicines or in other
botanical products in the United States and abroad.
- Aristolochic acids may
be found as a contaminant in herbal products used to treat a wide
variety of symptoms and diseases, such as arthritis, gout, and
inflammation.
- Aristolochic acid
(AA), a mixture of aristolochic acid I (AAI) and aristolochic acid
II (AAII), is present in Aristolochiaceae plants, many of which are
used as herbal folk remedies.
- A facile
reversed-phase HPLC method for the analysis of aristolochic acid
(AA) and aristolactam (AL) analogues was developed and used for the
quantitative determination and quality control of the traditional
Chinese medicine.
- Aristolochia spp. and
Asarum spp. are widely used in traditional Chinese medicine (TCM),
but those products are regulated as medicines in Taiwan.
- A reversed-phase high
performance liquid chromatographic method was established for the
quantitative determination of aristolochic acid in different parts
of Asarum heterotropoides produced in different places and growing
years.
- Aristolochic acids are
a family of acids found naturally in the plants Aristolochia and
Asarum, which grow throughout the United States and worldwide.
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